Prospective Evaluation of Germline Alterations in Patients With Exocrine Pancreatic Neoplasms,Journal of the National Cancer Institute

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Prospective Evaluation of Germline Alterations in Patients With Exocrine Pancreatic Neoplasms
Journal of the National Cancer Institute ( IF 9.9 ) Pub Date : 2018-02-28 , DOI: 10.1093/jnci/djy024
Maeve A Lowery _{1,

2} , Winston Wong _{1,

3} , Emmet J Jordan ₁ , Jonathan W Lee ₁ , Yelena Kemel ₄ , Joseph Vijai _{4,

5} , Diana Mandelker ₆ , Ahmet Zehir _{4,

5} , Marinela Capanu ₇ , Erin Salo-Mullen ₄ , Angela G Arnold ₄ , Kenneth H Yu _{1,

2,

3} , Anna M Varghese _{1,

2,

3} , David P Kelsen _{1,

2,

3} , Robin Brenner _{1,

2} , Erica Kaufmann _{1,

2} , Vignesh Ravichandran _{4,

5} , Semanti Mukherjee ₄ , Michael F Berger _{5,

6} , David M Hyman _{1,

3,

5} , David S Klimstra ₆ , Ghassan K Abou-Alfa _{1,

3} , Catherine Tjan ₁ , Christina Covington ₁ , Hannah Maynard ₁ , Peter J Allen _{2,

8} , Gokce Askan _{2,

6} , Steven D Leach _{2,

8} , Christine A Iacobuzio-Donahue ₂ , Mark E Robson _{1,

4} , Kenneth Offit _{1,

4} , Zsofia K Stadler _{1,

3,

4} , Eileen M O'Reilly _{1,

2,

3}

Affiliation

Identification of pathogenic germline alterations (PGAs) has important clinical and therapeutic implications in pancreas cancer. We performed comprehensive germline testing (GT) in an unselected prospective cohort of patients with exocrine pancreatic neoplasms with genotype and phenotype association to facilitate identification of prognostic and/or predictive biomarkers and examine potential therapeutic implications.

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