Magnetic molecularly imprinted polymers (MMIPs) were prepared for cocaine recognition by bulk polymerization in the presence of magnetic nanoparticles (MNPs). Two reagents (polyethylene glycol (PEG) and 3-(trimethoxysilyl)propyl methacrylate (V)) were used for MNPs modification. MMIPs were characterized and compared in terms of loading capacity, reusability, accuracy and precision for the extraction of cocaine from saliva samples. It was observed that V-MMIPs gave higher physical stability than PEG-MMIPs. Thus, V-MMIP were used for the analysis of cocaine users saliva. The developed procedure based on ion mobility spectrometry (IMS) provided limits of detection and quantification of 4 and 14 μg L⁻¹, respectively, and recoveries in cocaine free saliva samples spiked at 80, 270 and 560 μg L⁻¹ ranging from 80 to 99%. Results found by the proposed method were statistically comparable to those obtained by two reference procedures; a lateral flow immunoassay and an ultra-high performance liquid chromatography coupled with tandem mass spectrometry. Therefore, MMIP-IMS can be considered as a fast, selective and sensitive alternative to reference methods with affordable cost avoiding the requirement of skilled operator.

磁性分子印迹聚合物（MMIPs）制备用于在磁性纳米颗粒（MNPs）存在下通过本体聚合进行可卡因识别。两种试剂（聚乙二醇（PEG）和甲基丙烯酸3-（三甲氧基甲硅烷基）丙酯（V））用于修饰MNP。从唾液样品中提取可卡因的能力，可重复使用性，准确性和精密度方面，对MMIP进行了表征和比较。观察到V-MMIP比PEG-MMIP具有更高的物理稳定性。因此，V-MMIP被用于可卡因使用者唾液的分析。基于离子迁移谱（IMS）的已开发程序分别提供了4μgL ^-1和14μgL ^-1的检测和定量极限，以及加标为80μgL ^-1和560μgL ^-1的无可卡因唾液样品的回收率从80％到99％不等。通过提议的方法发现的结果在统计学上可与通过两种参考程序获得的结果进行统计学比较。侧流免疫分析和超高效液相色谱-串联质谱联用。因此，可以将MMIP-IMS视为参考方法的快速，选择性和灵敏的替代方法，且价格合理，从而避免了熟练操作人员的需求。