Self-Assembly of Partially Alkylated Dextran-graft-poly[(2-dimethylamino)ethyl methacrylate] Copolymer Facilitating Hydrophobic/Hydrophilic Drug Delivery and Improving Conetwork Hydrogel Properties,Biomacromolecules

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Self-Assembly of Partially Alkylated Dextran-graft-poly[(2-dimethylamino)ethyl methacrylate] Copolymer Facilitating Hydrophobic/Hydrophilic Drug Delivery and Improving Conetwork Hydrogel Properties
Biomacromolecules ( IF 5.5 ) Pub Date : 2018-02-27 00:00:00 , DOI: 10.1021/acs.biomac.8b00015
Arvind K. Singh Chandel ₁ , Bhingaradiya Nutan ₁ , Ishan H. Raval ₁ , Suresh K. Jewrajka ₁

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Key issues of injectable hydrogels are incapability of loading hydrophobic drugs due to insolubility of drugs in aqueous prepolymer solution as well as in hydrogel matrix, and high water swelling, which leads to poor mechanical and bioadhesive properties. Herein, we report that self-assembly of partially long-chain alkylated dextran-graft-poly[(2-dimethylamino)ethyl methacrylate] copolymer in aqueous solution could encapsulate pyrene, a hydrophobic probe, griseofulvin, a hydrophobic antifungal drug, and ornidazole, a hydrophilic antibiotic. Addition of activated chloride terminated poly(ethylene glycol) (PEG) into the guest molecules loaded copolymer solution produced an injectable dextran-graft-poly[(2-dimethylamino)ethyl methacrylate]-linked-PEG conetwork hydrogel. The alkylated hydrogels exhibited zero order release kinetics and were mechanically tough (50–54 kPa storage modulus) and bioadhesive (8–9 kPa). The roles of alkyl chains and dextran on the drug loading-release behavior, degradation behavior, gelation time, and the mechanical property of the hydrogels have been studied in details. Additionally, DNA hybrid composite hydrogel was formed owing to the cationic nature of the prepolymer solution and the hydrogel. Controlled alkylation of a prepolymer thus highlights the potential to induce and enhance the hydrogel property.

中文翻译：

部分烷基化的葡聚糖接枝-聚[（2-二甲基氨基）乙基甲基丙烯酸酯]共聚物的自组装，促进疏水/亲水药物传递并改善共网络水凝胶性能

可注射水凝胶的关键问题是由于药物在预聚物水溶液以及水凝胶基质中的不溶性而无法装载疏水性药物，并且水溶胀度高，从而导致较差的机械和生物粘附性能。本文中，我们报道了部分长链烷基化葡聚糖接枝的聚[[（2-二甲基氨基）乙基甲基丙烯酸酯]共聚物在水溶液中的自组装可以包埋pyr，疏水探针，灰黄霉素，疏水性抗真菌药和奥硝唑，亲水性抗生素。将活化的氯化物封端的聚乙二醇（PEG）添加到载有客体分子的共聚物溶液中，产生了可注射的葡聚糖接枝物-聚[甲基丙烯酸（2-二甲基氨基）乙酯] -PEG共网络水凝胶。烷基化水凝胶表现出零级释放动力学，具有机械韧性（50-54 kPa储能模量）和生物粘附性（8-9 kPa）。详细研究了烷基链和右旋糖酐对药物负载-释放行为，降解行为，胶凝时间和水凝胶力学性能的作用。另外，由于预聚物溶液和水凝胶的阳离子性质，形成了DNA杂化复合水凝胶。因此，预聚物的受控烷基化突出了诱导和增强水凝胶性质的潜力。

更新日期：2018-02-27

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