Despite much effort to treat glioblastoma multiforme (GBM), the median survival of patients has not significantly improved. The high rate of tumor recurrence after tumor resection and the blood–brain barrier (BBB) decrease the treatment efficacy. Local drug delivery at the surgical resection site via implantable electrospun nanofibers not only circumvents the BBB, but can also reduce the rate of tumor recurrence. Nanofibers can provide a sustained release and a high concentration of chemotherapeutics at the tumor vicinity, while decreasing their systemic exposure and toxicity. In another scenario, aligned nanofibers can mimic the topographical features of the brain extracellular matrix (ECM), which can be utilized for in vitro studies on GBM cell migration. This strategy is beneficial to investigate the interactions of tumor cells with the microenvironment which has a dominant role in regulating tumor formation, progression, and metastasis.

尽管为治疗多形性胶质母细胞瘤（GBM）付出了很多努力，但患者的中位生存期并未显着改善。肿瘤切除后的高肿瘤复发率和血脑屏障（BBB）降低了治疗效果。通过植入式电纺纳米纤维在手术切除部位的局部药物递送不仅可以规避血脑屏障，还可以降低肿瘤的复发率。纳米纤维可在肿瘤附近提供持续释放和高浓度的化学治疗，同时降低其全身暴露和毒性。在另一种情况下，对齐的纳米纤维可以模仿大脑细胞外基质（ECM）的地形特征，可用于体外GBM细胞迁移的研究。该策略有利于研究肿瘤细胞与微环境的相互作用，微环境在调节肿瘤形成，进展和转移中起主要作用。