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Polymer–Lipid Microparticles for Pulmonary Delivery
Langmuir ( IF 3.7 ) Pub Date : 2018-02-27 00:00:00 , DOI: 10.1021/acs.langmuir.7b03645 Georgios K. Eleftheriadis 1 , Melpomeni Akrivou 2 , Nikolaos Bouropoulos 3, 4 , John Tsibouklis 5 , Ioannis S. Vizirianakis 2 , Dimitrios G. Fatouros 1
Langmuir ( IF 3.7 ) Pub Date : 2018-02-27 00:00:00 , DOI: 10.1021/acs.langmuir.7b03645 Georgios K. Eleftheriadis 1 , Melpomeni Akrivou 2 , Nikolaos Bouropoulos 3, 4 , John Tsibouklis 5 , Ioannis S. Vizirianakis 2 , Dimitrios G. Fatouros 1
Affiliation
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Toward engineering approaches that are designed to optimize the particle size, morphology, and mucoadhesion behavior of the particulate component of inhaler formulations, this paper presents the preparation, physicochemical characterization, and preliminary in vitro evaluation of multicomponent polymer–lipid systems that are based on “spray-drying engineered” α-lactose monohydrate microparticles. The formulations combine an active (budesonide) with a lung surfactant (dipalmitoylphosphatidylcholine) and with materials that are known for their desirable effects on morphology (polyvinyl alcohol), aerosolization (l-leucine), and mucoadhesion (chitosan). The effect of the composition of formulations on the morphology, distribution, and in vitro mucoadhesion profiles is presented along with “Calu-3 cell monolayers” data that indicate good cytocompatibility and also with simulated-lung-fluid data that are consistent with the therapeutically useful release of budesonide.
中文翻译：
用于肺部输送的聚合物脂质微粒
旨在优化吸入器配方中颗粒成分的粒径，形态和粘膜粘附行为的工程方法，本文介绍了基于“喷雾干燥设计的α-乳糖一水合物微粒。该制剂与肺表面活性剂（二棕榈酰卵磷脂），并用已知为他们所希望的效果上的形态（聚乙烯醇）材料，气雾化（结合活性（布地奈德）升-亮氨酸）和粘膜粘附（壳聚糖）。与“ Calu-3细胞单层”数据（表明良好的细胞相容性）以及与治疗有用的模拟肺流体数据一起，介绍了制剂组成对形态，分布和体外粘膜粘附谱的影响。布地奈德的释放。
更新日期：2018-02-27
中文翻译：
用于肺部输送的聚合物脂质微粒
旨在优化吸入器配方中颗粒成分的粒径，形态和粘膜粘附行为的工程方法，本文介绍了基于“喷雾干燥设计的α-乳糖一水合物微粒。该制剂与肺表面活性剂（二棕榈酰卵磷脂），并用已知为他们所希望的效果上的形态（聚乙烯醇）材料，气雾化（结合活性（布地奈德）升-亮氨酸）和粘膜粘附（壳聚糖）。与“ Calu-3细胞单层”数据（表明良好的细胞相容性）以及与治疗有用的模拟肺流体数据一起，介绍了制剂组成对形态，分布和体外粘膜粘附谱的影响。布地奈德的释放。
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