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Biologically active quinoline and quinazoline alkaloids part II
Medicinal Research Reviews ( IF 10.9 ) Pub Date : 2018-02-27 , DOI: 10.1002/med.21492
Xiao-Fei Shang,Susan L. Morris-Natschke,Guan-Zhou Yang,Ying-Qian Liu,Xiao Guo,Xiao-Shan Xu,Masuo Goto,Jun-Cai Li,Ji-Yu Zhang,Kuo-Hsiung Lee

To follow‐up on our prior Part I review, this Part II review summarizes and provides updated literature on novel quinoline and quinazoline alkaloids isolated during the period of 2009‒2016, together with the biological activity and the mechanisms of action of these classes of natural products. Over 200 molecules with a broad range of biological activities, including antitumor, antiparasitic and insecticidal, antibacterial and antifungal, cardioprotective, antiviral, anti‐inflammatory, hepatoprotective, antioxidant, anti‐asthma, antitussive, and other activities, are discussed. This survey should provide new clues or possibilities for the discovery of new and better drugs from the original naturally occurring quinoline and quinazoline alkaloids.

中文翻译:

具有生物活性的喹啉和喹唑啉生物碱第二部分

为了跟进我们之前的第一部分综述,该第二部分综述总结并提供了有关2009-2016年间分离的新型喹啉和喹唑啉生物碱的生物学信息以及这些类别天然药物的作用机理的最新文献。产品。讨论了200多种具有广泛生物学活性的分子,包括抗肿瘤,抗寄生虫和杀虫,抗菌和抗真菌,心脏保护,抗病毒,抗炎,保肝,抗氧化,抗哮喘,镇咳药和其他活性。这项调查应为从原始的天然喹啉和喹唑啉生物碱中发现新的更好的药物提供新的线索或可能性。
更新日期:2018-02-27
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