The self-assembled microstructures of the bottlebrush polymers in aqueous solution are investigated by dissipative particle dynamic simulation. A series of structures, such as cylinder, sphere, lamella, perforated lamella, and network, are obtained from the solutions at various concentrations. These structures are arranged into several phase diagrams constructed by the main and side chains in various solution concentrations, and we analyze the influence of chain length on structural formation. We also investigate the resulting cylinders and spheres that interact with the lipid bilayer membranes in the dynamic processes. Two phagocytic models are observed in the phagocytic processes of the bottlebrush polymer particles with spherical and cylindrical shapes. The phagocytic processes are analyzed by the energies and wrapping percentages, in which the initial conditions are also evaluated with the velocities in the dynamic processes. The observations on these self-assembly and interaction process provide promising approaches for designing and understanding polymer particles and their phagocytic processes in the solutions.

通过耗散粒子动力学模拟研究了牙刷聚合物在水溶液中的自组装微观结构。从溶液中获得各种浓度的一系列结构，例如圆柱体，球体，薄片，多孔薄片和网状结构。这些结构排列成由主链和侧链在不同溶液浓度下构建的几个相图，并且我们分析了链长对结构形成的影响。我们还研究了在动态过程中与脂质双层膜相互作用的圆柱体和球体。在球形和圆柱形的牙刷聚合物颗粒的吞噬过程中观察到两个吞噬模型。通过能量和包裹百分比来分析吞噬过程，其中初始条件也可以通过动态过程中的速度进行评估。这些自组装和相互作用过程的观察结果为设计和理解溶液中的聚合物颗粒及其吞噬过程提供了有希望的方法。