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Facile Synthesis of Ni(OH)2 Modified Disposable Pencil Graphite Electrode and its Application for Highly Sensitive Non‐enzymatic Glucose Sensor
Electroanalysis ( IF 2.7 ) Pub Date : 2018-02-27 , DOI: 10.1002/elan.201800002 Mohamed Lyamine Chelaghmia 1 , Mouna Nacef 1 , Abed Mohamed Affoune 1 , Maxime Pontié 2 , Tahar Derabla 1
Electroanalysis ( IF 2.7 ) Pub Date : 2018-02-27 , DOI: 10.1002/elan.201800002 Mohamed Lyamine Chelaghmia 1 , Mouna Nacef 1 , Abed Mohamed Affoune 1 , Maxime Pontié 2 , Tahar Derabla 1
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In this study, a low‐cost, disposable, sensitive and selective electrochemical sensor was developed for glucose determination, which is based on a pencil graphite electrode (PGE) modified with nickel hydroxide. Cyclic voltammetry was used to deposit nickel on PGE. The morphology and composition of the unmodified and modified PGE electrodes were characterized by field‐emission scanning electron microscopy (FE‐SEM), atomic force microscopy (AFM) and energy‐dispersive X‐ray spectroscopy (EDX). The performance of the as modified electrode towards the electrooxidation of glucose in alkaline media was evaluated with cyclic voltammetry and amperometry techniques. A linear relationship between the concentration of glucose and oxidation peak currents was observed in two concentration ranges of 0.004–3.5 mM and 3.5–9.0 mM. The detection limit was 2 μM at signal‐to‐noise ratio of 3. In addition to a fast response time (<2 s), the proposed sensor preserved 93 % of its original response towards glucose after 28 days. Also, the sensor showed a good reproducibility and high selectivity for glucose oxidation in the presence of common interfering species. The use of Ni(OH)2/PGE sensor was successfully tested in the determination of glucose in human blood serum for the first time in the literature.
中文翻译：
Ni（OH）2修饰的一次性笔形石墨电极的简便合成及其在高灵敏度非酶葡萄糖传感器中的应用
在这项研究中，开发了一种用于葡萄糖测定的低成本，一次性，灵敏和选择性的电化学传感器，该传感器基于氢氧化镍修饰的铅笔状石墨电极（PGE）。循环伏安法用于在PGE上沉积镍。通过场发射扫描电子显微镜（FE-SEM），原子力显微镜（AFM）和能量色散X射线光谱（EDX）对未修饰和修饰的PGE电极的形态和成分进行了表征。用循环伏安法和安培法技术评估了修饰电极对葡萄糖在碱性介质中的电氧化的性能。在0.004–3.5 mM和3.5–9.0 mM的两个浓度范围内观察到了葡萄糖浓度与氧化峰值电流之间的线性关系。信噪比为3时，检测极限为2μM。除了快速响应时间（<2 s）外，拟议的传感器在28天后还保留了其对葡萄糖的原始响应的93％。同样，在常见干扰物种的存在下，该传感器对葡萄糖氧化也显示出良好的重现性和高选择性。Ni（OH）的使用2 / PGE传感器在文献中首次成功地用于测定人血清中的葡萄糖。
更新日期：2018-02-27
中文翻译：
Ni（OH）2修饰的一次性笔形石墨电极的简便合成及其在高灵敏度非酶葡萄糖传感器中的应用
在这项研究中，开发了一种用于葡萄糖测定的低成本，一次性，灵敏和选择性的电化学传感器，该传感器基于氢氧化镍修饰的铅笔状石墨电极（PGE）。循环伏安法用于在PGE上沉积镍。通过场发射扫描电子显微镜（FE-SEM），原子力显微镜（AFM）和能量色散X射线光谱（EDX）对未修饰和修饰的PGE电极的形态和成分进行了表征。用循环伏安法和安培法技术评估了修饰电极对葡萄糖在碱性介质中的电氧化的性能。在0.004–3.5 mM和3.5–9.0 mM的两个浓度范围内观察到了葡萄糖浓度与氧化峰值电流之间的线性关系。信噪比为3时，检测极限为2μM。除了快速响应时间（<2 s）外，拟议的传感器在28天后还保留了其对葡萄糖的原始响应的93％。同样，在常见干扰物种的存在下，该传感器对葡萄糖氧化也显示出良好的重现性和高选择性。Ni（OH）的使用2 / PGE传感器在文献中首次成功地用于测定人血清中的葡萄糖。
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