Synthesis of trans-disubstituted-2,3-dihydrobenzofurans by a formal [4 + 1] annulation between para-quinone methides and sulfonium salts†,Organic Chemistry Frontiers

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Synthesis of trans-disubstituted-2,3-dihydrobenzofurans by a formal [4 + 1] annulation between para-quinone methides and sulfonium salts†
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2018-02-27 00:00:00 , DOI: 10.1039/c8qo00008e
Ying Zhi _{1,

2,

3,

4} , Kun Zhao _{1,

2,

3,

4} , Carolina von Essen _{5,

6,

7,

8} , Kari Rissanen _{5,

6,

7,

8} , Dieter Enders _{1,

2,

3,

4}

Affiliation

An efficient protocol for the synthesis of trans-disubstituted-2,3-dihydrobenzofurans through [4 + 1] annulation of para-quinone methides with sulfonium salts has been developed. Under very mild conditions this unprecedented reaction occurs in good to excellent yields (up to 99%), offering a straightforward access to a variety of 2,3-dihydrobenzofurans.

中文翻译：

通过对苯醌甲基化物和sulf盐之间的正规[4 +1]环合反应合成反式-二取代-2,3-二氢苯并呋喃†

已开发出一种有效的方案，可通过对位醌甲基化物与sulf盐的[4 +1]环合反应合成反式-二取代-2,3-二氢苯并呋喃。在非常温和的条件下，这种空前的反应以良好的产率（高达99％）发生，从而可以直接获得各种2,3-二氢苯并呋喃。

更新日期：2018-02-27

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