Sterol regulatory element-binding proteins (SREBPs) are a family of membrane-bound transcription factors that activate genes encoding enzymes required for synthesis of cholesterol and unsaturated fatty acids. SREBPs are controlled by multiple mechanisms at the level of mRNA synthesis, proteolytic activation, and transcriptional activity. In this review, we summarize the recent findings that contribute to the current understanding of the regulation of SREBPs and their physiologic roles in maintenance of lipid homeostasis, insulin signaling, innate immunity, and cancer development.

中文翻译：

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SREBPs在脂质代谢，胰岛素信号传导及其他方面

甾醇调节元件结合蛋白（SREBP）是一类膜结合转录因子，可激活编码胆固醇和不饱和脂肪酸合成所需酶的基因。SREBP在mRNA合成，蛋白水解激活和转录活性水平上受多种机制控制。在这篇综述中，我们总结了最近的发现，这些发现有助于对SREBPs的调控及其在维持脂质稳态，胰岛素信号传导，先天免疫和癌症发展中的生理作用的当前理解。