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Drug Delivery: Graphene‐Based MicroRNA Transfection Blocks Preosteoclast Fusion to Increase Bone Formation and Vascularization (Adv. Sci. 2/2018)
Advanced Science ( IF 14.3 ) Pub Date : 2018-02-27 , DOI: 10.1002/advs.201870009
Ce Dou 1 , Ning Ding 1 , Fei Luo 1 , Tianyong Hou 1 , Zhen Cao 2 , Yun Bai 2 , Chuan Liu 2 , Jianzhong Xu 1 , Shiwu Dong 2
Affiliation  

In article number 1700578, Jianzhong Xu, Shiwu Dong, and co‐workers report the development of a graphene‐based miRNA transfection system that uses a polyethylenimine (PEI) functionalized graphene oxide complex loaded with miR‐7b plasmid. The system efficiently delivers the miR‐7b plasmid into bone marrow macrophases and reduces the expression of target protein dendritic cell‐specific transmembrane protein, specifically targeting cell–cell fusion to block the formation of mature osteoclasts while preserving beneficial preosteoclasts.
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中文翻译:

药物输送:基于石墨烯的MicroRNA转染阻止破骨细胞融合以增加骨形成和血管化(Adv.Sci.2 / 2018)

徐建中,董世武和同事在文章1700578中报告了基于石墨烯的miRNA转染系统的开发,该系统使用了载有miR-7b质粒的聚乙烯亚胺(PEI)功能化氧化石墨烯复合物。该系统可将miR-7b质粒有效地递送至骨髓巨相,并降低靶蛋白树突状细胞特异性跨膜蛋白的表达,特别是靶向细胞间融合以阻止成熟破骨细胞的形成,同时保留有益的破骨细胞。
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更新日期:2018-02-27
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