A novel series of amphiphilic cobalt-cage derivatives (ACCD), bearing a diaza-crown bridge and varying alkyl chains, facilitate ion transport across biomembrane models via self-aggregation. In this study, compression isotherm analyses and atomic force microscopy (AFM) were used to assess the interactions of these amphiphiles with Langmuir monolayers of dipalmitoylphosphatidylcholine (DPPC) in order to elucidate electrostatic and steric contributions to ion transport. The stability and compressibility of DPPC monolayers are disrupted by ACCD molecules with short (C₁₂) alkyl chains. These top-heavy amphiphiles (large cone angles) create voids at the interface of the hydrophobic/aqueous layer leading to monolayer expansion and packing efficiency of the aliphatic chains is disrupted. Long-tailed analogues (C₁₆, C₁₈) are cohesively integrated into DPPC monolayers due to their smaller cone angles at the interfacial region and increased hydrocarbon compatibility in the hydrophobic region. Thermodynamic data indicate the formation of electrostatic complexes between DPPC and longer-tailed amphiphiles consistent with AFM observations of aggregate structures at the corresponding concentrations.

一系列新的两亲性钴笼衍生物（ACCD），带有二氮杂冠桥和变化的烷基链，可通过自聚集促进离子跨生物膜模型的转运。在这项研究中，压缩等温线分析和原子力显微镜（AFM）用于评估这些两亲物与二棕榈酰磷脂酰胆碱（DPPC）的Langmuir单层的相互作用，以阐明静电和空间对离子迁移的贡献。具有短（C ₁₂）烷基链的ACCD分子破坏了DPPC单层的稳定性和可压缩性。这些最重的两亲物（大锥角）在疏水/水层的界面处产生空隙，导致单分子层膨胀，脂族链的堆积效率被破坏。长尾类似物（C由于其在界面区域的较小锥角和在疏水区域的增加的烃相容性，所以图₁₆，C ₁₈）内聚地结合到DPPC单层中。热力学数据表明，DPPC与长尾两亲物之间形成了静电配合物，与相应浓度下聚集体结构的AFM观察结果一致。