We grafted human spinal cord-derived neural progenitor cells (NPCs) into sites of cervical spinal cord injury in rhesus monkeys (Macaca mulatta). Under three-drug immunosuppression, grafts survived at least 9 months postinjury and expressed both neuronal and glial markers. Monkey axons regenerated into grafts and formed synapses. Hundreds of thousands of human axons extended out from grafts through monkey white matter and synapsed in distal gray matter. Grafts gradually matured over 9 months and improved forelimb function beginning several months after grafting. These findings in a 'preclinical trial' support translation of NPC graft therapy to humans with the objective of reconstituting both a neuronal and glial milieu in the site of spinal cord injury.

中文翻译：

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人类神经干细胞移植物对灵长类脊髓的修复作用。

我们将人类脊髓源性神经祖细胞（NPC）移植到恒河猴（猕猴）颈脊髓损伤的部位。在三药免疫抑制下，移植物在损伤后存活至少9个月，并表达神经元和神经胶质标志物。猴轴突再生为移植物并形成突触。成千上万的人类轴突从猴子的白质从移植物中伸出，并突触到远端的灰质中。移植物在9个月内逐渐成熟，并在移植后数月开始改善前肢功能。“临床前试验”中的这些发现支持NPC移植疗法向人类的转化，目的是在脊髓损伤部位重建神经元和神经胶质细胞。