Recognition of virus-derived nucleic acids by host pattern recognition receptors (PRRs) is crucial for early defense against viral infections. Recent studies revealed that PRRs also include several newly identified DNA sensors, most of which could activate the downstream adaptor stimulator of interferon genes (STING) and lead to the production of host antiviral factors. Herpes simplex virus 1 (HSV-1) is extremely successful in establishing effective infections, due to its capacity to counteract host innate antiviral responses. In this Gem, I summarize the most recent findings on the molecular mechanisms utilized by HSV-1 to target different steps of the cellular DNA-sensor-mediated antiviral signal pathway.

宿主模式识别受体（PRR）对病毒衍生核酸的识别对于早期防御病毒感染至关重要。最近的研究表明，PRRs还包括几种新发现的DNA传感器，其中大多数可以激活干扰素基因下游接头刺激物（STING）并导致宿主抗病毒因子的产生。单纯疱疹病毒 1 (HSV-1) 在建立有效感染方面非常成功，因为它能够抵消宿主先天的抗病毒反应。在这篇 Gem 中，我总结了 HSV-1 利用分子机制来靶向细胞 DNA 传感器介导的抗病毒信号通路的不同步骤的最新发现。