In the Lancet Respiratory Medicine, Nadia Alam and colleagues¹ assessed prehospital administration of intravenous ceftriaxone 2000 mg in addition to usual care (fluid resuscitation and supplementary oxygen) in the ambulance for patients with suspected sepsis in the randomised controlled PHANTASi trial.¹ Unfortunately, this early intervention did not lead to improved sepsis survival compared with patients receiving usual care alone. Fewer patients died in the study (8% across both arms) than was predicted (40%) based on epidemiological studies at the time of the trial design.

中文翻译：

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败血症的院前抗生素：超越死亡率？

在《柳叶刀呼吸医学》杂志中，Nadia Alam及其同事[ ^1]在随机对照PHANTASi试验中，评估了院前对疑似脓毒症患者在救护车中静脉注射头孢曲松钠2000 mg以及常规护理（液体复苏和补充氧气）的情况。¹不幸的是，与仅接受常规护理的患者相比，这种早期干预并未导致败血症生存期的改善。在试验设计时，根据流行病学研究，在该研究中死亡的患者（双臂的8％）少于预期的比例（40％）。