The present study reports successful separations of enantiomers of selected chiral sulfoxides with very high separation factor in high-performance liquid chromatography by using chiral columns prepared with the chiral selector cellulose tris(4-chloro-3-methylphenylcarbamate). High separation factors were observed in polar organic, as well as in hydrocarbon-alcohol-type mobile phases. The key structural components of the solute for obtaining high chiral recognition are discussed as well as thermodynamic quantities of analyte adsorption on the chiral stationary phase were determined. Experiment aimed at the enantioselective extraction of racemates from solution are also described.

本研究报告通过使用由手性选择剂纤维素三（4-氯-3-甲基苯基氨基甲酸酯）制备的手性柱，在高效液相色谱中成功分离出具有非常高分离因子的所选手性亚砜的对映异构体。在极性有机物以及烃-醇型流动相中观察到高分离因子。讨论了用于获得高度手性识别的溶质的关键结构成分，并确定了在手性固定相上吸附的分析物的热力学量。还描述了旨在从溶液中对映体的对映体选择性萃取的实验。