Omics Advances in Ecotoxicology,Environmental Science & Technology

当前位置： X-MOL 学术 › Environ. Sci. Technol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Omics Advances in Ecotoxicology
Environmental Science & Technology ( IF 10.8 ) Pub Date : 2018-03-12 00:00:00 , DOI: 10.1021/acs.est.7b06494
Xiaowei Zhang ₁ , Pu Xia ₁ , Pingping Wang ₁ , Jianghu Yang ₁ , Donald J. Baird ₂

Affiliation

Toxic substances in the environment generate adverse effects at all levels of biological organization from the molecular level to community and ecosystem. Given this complexity, it is not surprising that ecotoxicologists have struggled to address the full consequences of toxic substance release at ecosystem level, due to the limits of observational and experimental tools to reveal the changes in deep structure at different levels of organization. -Omics technologies, consisting of genomics and ecogenomics, have the power to reveal, in unprecedented detail, the cellular processes of an individual or biodiversity of a community in response to environmental change with high sample/observation throughput. This represents a historic opportunity to transform the way we study toxic substances in ecosystems, through direct linkage of ecological effects with the systems biology of organisms. Three recent examples of -omics advance in the assessment of toxic substances are explored here: (1) the use of functional genomics in the discovery of novel molecular mechanisms of toxicity of chemicals in the environment; (2) the development of laboratory pipelines of dose-dependent, reduced transcriptomics to support high-throughput chemical testing at the biological pathway level; and (3) the use of eDNA metabarcoding approaches for assessing chemical effects on biological communities in mesocosm experiments and through direct observation in field monitoring. -Omics advances in ecotoxicological studies not only generate new knowledge regarding mechanisms of toxicity and environmental effect, improving the relevance and immediacy of laboratory toxicological assessment, but can provide a wholly new paradigm for ecotoxicology by linking ecological models to mechanism-based, systems biology approaches.

中文翻译：

Omics在生态毒理学方面的进展

从分子水平到社区和生态系统，环境中的有毒物质都会对生物组织的各个层面产生不利影响。鉴于这种复杂性，由于观测和实验工具的局限性无法揭示组织不同层次深层结构的变化，因此生态毒理学家努力解决有毒物质在生态系统水平释放的全部后果也就不足为奇了。-由基因组学和生态基因组学组成的组学技术，能够以空前的细节揭示个体或社区生物多样性的细胞过程，以应对环境变化，并具有很高的样品/观测通量。这是改变我们研究生态系统中有毒物质的方式的历史性机遇，通过将生态影响与生物体系统生物学直接联系起来。这里探讨了组学在评估有毒物质方面的最新进展的三个例子：（1）功能基因组学在发现化学物质对环境毒性的新分子机制中的应用；（2）开发剂量依赖性，减少转录组学的实验室管线，以支持生物途径水平的高通量化学检测；（3）使用eDNA元条形码技术评估中观实验中以及通过现场监测中的直接观察对生物群落的化学作用。-Omics在生态毒理学研究方面的进步不仅产生了有关毒性和环境影响机理的新知识，

更新日期：2018-03-12

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11