Physical Properties of Biomolecules at the Nanomaterial Interface,The Journal of Physical Chemistry B

当前位置： X-MOL 学术 › J. Phys. Chem. B › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Physical Properties of Biomolecules at the Nanomaterial Interface
The Journal of Physical Chemistry B ( IF 2.8 ) Pub Date : 2018-02-26 00:00:00 , DOI: 10.1021/acs.jpcb.8b00168
Cristina Rodriguez-Quijada ₁ , Maria Sánchez-Purrà ₁ , Helena de Puig ₂ , Kimberly Hamad-Schifferli _{1,

2}

Affiliation

The unique size and material dependent properties of nanoparticles have made them highly attractive for biological and medical applications. However, combining nanoparticles with biomolecules and biological environments has faced many challenges. These interface issues often involve protein denaturation, steric hindrance, and orientational issues for the biomolecule, which can impair function and decrease overall performance of the nanoparticle–biomolecule conjugate. Historically, our understanding of the physical and chemical properties of nanoparticle–biomolecule conjugates as appropriate tools and experimental techniques had to be determined. We discuss here selected examples investigating the fundamental physical properties of the interface between nanoparticles and DNA and proteins and protein coronas and how they have provided insight into the properties of the biomolecule when it is interfaced to a nanoparticle.

中文翻译：

纳米材料界面上生物分子的物理性质

纳米粒子的独特尺寸和材料依赖性使其在生物学和医学应用中具有很高的吸引力。然而，将纳米颗粒与生物分子和生物环境结合已经面临许多挑战。这些界面问题通常涉及生物分子的蛋白质变性，空间位阻和方向性问题，这可能会损害功能并降低纳米粒子-生物分子共轭物的整体性能。从历史上看，我们必须确定对纳米颗粒-生物分子共轭物的物理和化学性质的了解，并将其作为合适的工具和实验技术。

更新日期：2018-02-26

点击分享查看原文

点击收藏

阅读更多本刊最新论文