Abstract A commercial-scale generation of uniform and well-controlled soft microparticles is critical for therapeutic embolization, a minimally invasive, nonsurgical interventional therapeutic technique for the treatment of various conditions, including tumors, vascular lesions and hemorrhages. We report the generation of required embolic microparticles from an electrified meniscus of the precursor alginate solution. A micro-dripping regime is identified with electric Bond number BE being from 0.3 to 1 and Weber number We d d ∼ q 0.5 , f ∼ q - 0.15 B E 0.67 in this regime, with q being the dimensionless flow rate. Our results are valuable for effective production of therapeutic microparticles on a commercial scale from precursor solution of similar physical properties.

中文翻译：

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来自周期性脉动带电液体弯月面的工程栓塞微粒

摘要 商业规模生产均匀且控制良好的软微粒对于治疗栓塞至关重要，栓塞是一种微创、非手术介入治疗技术，用于治疗各种疾病，包括肿瘤、血管病变和出血。我们报告了从前体藻酸盐溶液的带电弯月面生成所需的栓塞微粒。确定微滴流状态，电键数 BE 为 0.3 到 1，韦伯数 We dd ∼ q 0.5 ，f ∼ q - 0.15 BE 0.67 在该状态下，q 是无量纲流速。我们的结果对于从具有相似物理特性的前体溶液以商业规模有效生产治疗性微粒很有价值。