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Layer-by-Layer Assembled Microgels Can Combine Conflicting Properties: Switchable Stiffness and Wettability without Affecting Permeability
Langmuir ( IF 3.7 ) Pub Date : 2018-02-26 00:00:00 , DOI: 10.1021/acs.langmuir.8b00047 Eliana Maza 1 , Catalina von Bilderling 1 , M. Lorena Cortez 1 , Gisela Díaz 1 , Micaela Bianchi , Lía I. Pietrasanta , Juan M. Giussi 1 , Omar Azzaroni 1
Langmuir ( IF 3.7 ) Pub Date : 2018-02-26 00:00:00 , DOI: 10.1021/acs.langmuir.8b00047 Eliana Maza 1 , Catalina von Bilderling 1 , M. Lorena Cortez 1 , Gisela Díaz 1 , Micaela Bianchi , Lía I. Pietrasanta , Juan M. Giussi 1 , Omar Azzaroni 1
Affiliation
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Responsive interfacial architectures of practical interest commonly require the combination of conflicting properties in terms of their demand upon material structure. Switchable stiffness, wettability, and permeability, key features for tissue engineering applications, are in fact known to be exclusively interdependent. Here, we present a nanoarchitectonic approach that decouples these divergent properties by the use of thermoresponsive microgels as building blocks for the construction of three-dimensional arrays of interconnected pores. Layer-by-layer assembled poly(N-isopropylacrylamide-co-methacrylic acid) microgel films were found to exhibit an increase in hydrophobicity, stiffness, and adhesion properties upon switching the temperature from below to above the lower critical solution temperature, whereas the permeability of redox probes through the film remained unchanged. Our findings indicate that the switch in hydrophilicity and nanomechanical properties undergone by the microgels does not compromise the porosity of the film, thus allowing the free diffusion of redox probes through the polymer-free volume of the submicrometer pores. This novel approach for decoupling conflicting properties provides a strategic route for creating tailorable scaffolds with unforeseen functionalities.
中文翻译：
逐层组装的微凝胶可以结合相互冲突的特性：可切换的刚度和润湿性，而不会影响渗透性
具有实用价值的响应性界面体系结构通常需要根据其对材料结构的需求来组合冲突的属性。实际上，可切换的刚度，润湿性和渗透性是组织工程应用的关键特征，实际上是相互依赖的。在这里，我们提出了一种纳米建筑方法，该方法通过使用热响应性微凝胶作为构建相互连接的孔的三维阵列的构建基块，将这些发散的特性解耦。层-层组装聚（Ñ -isopropylacrylamide-共当将温度从低于下限临界溶液温度切换到高于下临界溶液温度时，发现（甲基丙烯酸）微凝胶膜表现出疏水性，刚度和粘附特性的增加，而氧化还原探针通过膜的渗透性保持不变。我们的发现表明，微凝胶所经历的亲水性和纳米机械性能的变化不会损害膜的孔隙率，从而允许氧化还原探针通过亚微米孔的无聚合物体积自由扩散。这种解耦冲突属性的新颖方法为创建具有不可预见功能的可定制支架提供了战略途径。
更新日期：2018-02-26
中文翻译：
逐层组装的微凝胶可以结合相互冲突的特性：可切换的刚度和润湿性，而不会影响渗透性
具有实用价值的响应性界面体系结构通常需要根据其对材料结构的需求来组合冲突的属性。实际上，可切换的刚度，润湿性和渗透性是组织工程应用的关键特征，实际上是相互依赖的。在这里，我们提出了一种纳米建筑方法，该方法通过使用热响应性微凝胶作为构建相互连接的孔的三维阵列的构建基块，将这些发散的特性解耦。层-层组装聚（Ñ -isopropylacrylamide-共当将温度从低于下限临界溶液温度切换到高于下临界溶液温度时，发现（甲基丙烯酸）微凝胶膜表现出疏水性，刚度和粘附特性的增加，而氧化还原探针通过膜的渗透性保持不变。我们的发现表明，微凝胶所经历的亲水性和纳米机械性能的变化不会损害膜的孔隙率，从而允许氧化还原探针通过亚微米孔的无聚合物体积自由扩散。这种解耦冲突属性的新颖方法为创建具有不可预见功能的可定制支架提供了战略途径。
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