AbstractCytidine is regarded as an early marker of colon cancer. The authors describe a surface enhanced Raman scattering (SERS) technique to detect trace levels of cytidine in urine. The Raman band at 784 cm−1 can be acquired best. Compared to earlier methods, an improvement in detection sensitivity by a factor of 6.2 × 105 is achieved by using a magnetically induced method in which cytidine is captured in the vicinity of the SERS hot spots of the type Fe3O4/Au/Ag. Cytidine can be quantified at 1 nM levels by this method which is simple and reliable. Graphical AbstractClusters consisting of magnetite (Fe3O4) nanoparticles, gold nanoparticles and silver nanoparticles were prepared and used in a SERS based method for detection of cytidine in urine by using magnetic improvement. The lowest detectable concentration of cytidine are at the nM level.

中文翻译：

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使用 Fe3O4/Au/Ag 型磁化纳米颗粒对结肠癌生物标志物胞苷进行表面增强拉曼检测

摘要 胞苷被认为是结肠癌的早期标志物。作者描述了一种表面增强拉曼散射 (SERS) 技术来检测尿液中痕量的胞苷。可以最好地获得 784 cm-1 的拉曼谱带。与早期的方法相比，通过使用磁感应方法将检测灵敏度提高了 6.2 × 105，其中胞苷被捕获在 Fe3O4/Au/Ag 类型的 SERS 热点附近。通过这种简单可靠的方法，可以在 1 nM 水平上对胞苷进行定量。图形摘要 制备了由磁铁矿 (Fe3O4) 纳米粒子、金纳米粒子和银纳米粒子组成的簇，并将其用于基于 SERS 的方法，通过使用磁性改进检测尿液中的胞苷。胞苷的最低可检测浓度处于 nM 水平。