Efficient Synthesis of Light‐Triggered Circular Antisense Oligonucleotides Targeting Cellular Protein Expression,ChemBioChem

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Efficient Synthesis of Light‐Triggered Circular Antisense Oligonucleotides Targeting Cellular Protein Expression
ChemBioChem ( IF 2.6 ) Pub Date : 2018-04-17 , DOI: 10.1002/cbic.201800012
Linlin Yang ₁ , Hyun Bum Kim ₂ , Jai-Yoon Sul ₂ , Sean B Yeldell ₁ , James H Eberwine ₂ , Ivan J Dmochowski ₁

Affiliation

It just clicks: Caged circular oligonucleotides allow photomodulation of gene expression in living cells. An efficient route for cyclizing an antisense oligodeoxynucleotide (AS‐ODN) incorporating a photocleavable linker (PL) is explored. Oligo cyclization is achieved for several sequences in nearly quantitative yields through intramolecular copper(I)‐catalyzed azide–alkyne cycloaddition.

中文翻译：

高效合成光触发环状反义寡核苷酸靶向细胞蛋白表达

只需点击一下即可：笼状环状寡核苷酸可以对活细胞中的基因表达进行光调节。探索了一种有效的环化包含光可裂解接头（PL）的反义寡脱氧核苷酸（AS-ODN）的途径。通过分子内铜 (I) 催化的叠氮化物-炔环加成，可以以接近定量的产率实现多个序列的寡环化。

更新日期：2018-04-17

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