Access to Enantioenriched Organosilanes from Enals and β‐Silyl Enones: Carbene Organocatalysis,Angewandte Chemie International Edition

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Access to Enantioenriched Organosilanes from Enals and β‐Silyl Enones: Carbene Organocatalysis
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2018-03-15 , DOI: 10.1002/anie.201800483
Yuxia Zhang ₁ , Jie Huang ₁ , Yingying Guo ₁ , Lin Li ₁ , Zhenqian Fu ₁ , Wei Huang _{1,

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Affiliation

Herein, an efficient route to enantioenriched organosilanes, containing two consecutive stereogenic centers, from enals and β‐silyl enones under carbene organocatalysis is described. Under mild reaction conditions, this transition‐metal‐free strategy exhibits a broad substrate scope, and excellent diastereo‐ and enantioselectivity.

中文翻译：

从Enals和β-甲硅烷基烯酮中获得对映体富集的有机硅烷：碳烯有机催化

在本文中，描述了在卡宾有机催化下从烯类和β-甲硅烷基烯酮到富含对映体富集的有机硅烷的有效途径，该对映体包含两个连续的立体异构中心。在温和的反应条件下，这种无过渡金属的策略具有广泛的底物范围，以及出色的非对映和对映选择性。

更新日期：2018-03-15

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