In this present study, poly (N-isopropylacrylamide) as a thermo-sensitive agent was grafted onto magnetic nanoparticles, then ethylenediamine and methylmethacrylate were used to synthesize the first generation of poly amidoamine (PAMAM) dendrimers successively and the process continued alternatively until the ten generations of dendrimers. The synthesized nanocomposite was investigated using Fourier transform infrared spectrometry, thermalgravimetry analysis, X-ray diffractometry, elemental analysis and vibrating-sample magnetometer. The particle size and morphology were characterized using dynamic light scattering, field emission scanning electron microscopy and transmission electron microscopy. Batch experiments were conducted to investigate the parameters affecting adsorption and desorption of rivaroxaban by synthesized nanocomposite. The maximum sorption of rivaroxaban by the synthesized nanocomposite was obtained at pH of 8. The resulting grafted magnetic nanoparticle dendrimers were applied for extraction of rivaroxaban from biologic human liquids and medicinal samples. The specifications of rivaroxaban sorbed by a magnetic nanoparticle dendrimer showed good accessibility and high capacity of the active sites within the dendrimers. Urine and drug matrix extraction recoveries of more than 92.5 and 99.8 were obtained, respectively.

在本研究中，将聚（N-异丙基丙烯酰胺）作为热敏剂接枝到磁性纳米颗粒上，然后使用乙二胺和甲基丙烯酸甲酯依次合成第一代聚酰胺基（PAMAM）树枝状大分子，然后继续进行该过程，直到十个几代树状聚合物。使用傅里叶变换红外光谱，热重分析，X射线衍射，元素分析和振动样品磁力计对合成的纳米复合材料进行了研究。使用动态光散射，场发射扫描电子显微镜和透射电子显微镜来表征粒度和形态。进行批处理实验以研究影响合成的纳米复合材料对利伐沙班的吸附和解吸的参数。在8的pH值下，合成的纳米复合材料对rivaroxaban具有最大的吸附作用。将所得的接枝磁性纳米粒子树状聚合物用于从生物人体液体和药物样品中提取rivaroxaban。磁性纳米颗粒树枝状聚合物吸附的利伐沙班的规格显示出良好的可及性和树枝状聚合物中活性位点的高容量。尿液和药物基质的提取回收率分别超过92.5和99.8。磁性纳米颗粒树枝状聚合物吸附的利伐沙班的规格显示出良好的可及性和树枝状聚合物中活性位点的高容量。尿液和药物基质的提取回收率分别超过92.5和99.8。磁性纳米颗粒树枝状聚合物吸附的利伐沙班的规格显示出良好的可及性和树枝状聚合物中活性位点的高容量。尿液和药物基质的提取回收率分别超过92.5和99.8。