In this article, we have unveiled the aggregation behavior of a potent chemotherapeutic drug, doxorubicin hydrochloride (Dox) in a well-known imidazolium based surface active ionic liquid (SAIL), 1-octyl-3-methylimidazolium chloride (C₈mimCl). The aggregates formed by Dox in C₈mimCl have been characterized using dynamic light scattering (DLS), fluorescence lifetime imaging microscopy (FLIM), high-resolution transmission electron microscopy (HR-TEM), analytical transmission electron microscopy (analytical TEM), field emission scanning electron microscopy (FESEM), atomic force microscopy (AFM), and Fourier-transform infrared spectroscopy (FTIR) measurements. It is found that Dox forms large spherical aggregates in the presence of C₈mimCl SAIL. We have also explored the driving force behind this aggregation behavior of Dox in C₈mimCl. Furthermore, it is observed that in the presence of a common bile salt, sodium cholate (NaCh), Dox/C₈mimCl spherical aggregates disrupt to form rodlike fibrillar aggregates. Therefore, formation of spherical aggregates and also its disruption into rodlike fibrillar aggregates have been performed, and this is expected to open a new scope for the design of a new generation smart drug delivery system where the drug itself aggregates to form the delivery system.

中文翻译：

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揭示阿霉素盐酸盐在1-Octyl-3-甲基咪唑鎓氯化物水溶液中的聚集行为以及胆汁盐对这些聚集体的影响：微观研究

在本文中，我们揭示了一种有效的化疗药物盐酸阿霉素（Dox）在著名的咪唑基表面活性离子液体（SAIL），1-辛基-3-甲基咪唑鎓氯化物（C ₈ mimCl）中的聚集行为。Dox在C ₈ mimCl中形成的聚集体已通过动态光散射（DLS），荧光寿命成像显微镜（FLIM），高分辨率透射电子显微镜（HR-TEM），分析透射电子显微镜（分析TEM），场进行了表征发射扫描电子显微镜（FESEM），原子力显微镜（AFM）和傅立叶变换红外光谱（FTIR）测量。发现在C ₈存在下Dox形成大的球形聚集体mimCl航行。我们还探索了Dox在C ₈ mimCl中这种聚集行为背后的驱动力。此外，观察到在胆汁盐，胆酸钠（NaCh），Dox / C ₈ mimCl球形聚集体的存在下破裂，形成棒状原纤维聚集体。因此，已经进行了球形聚集体的形成以及其向棒状原纤维聚集体的破坏，这有望为新一代智能药物输送系统的设计开辟新的领域，其中药物本身会聚集形成输送系统。