Abstract pH-sensitive chitosan/alginate/tripolyphosphate (Ch/Alg/TPP) hydrogel membranes based on chitosan/alginate (Ch/Alg) polyelectrolyte complex and crosslinking agent tripolyphosphate (TPP) were synthesized. An effect of TPP-crosslinking on the molecular structure, crystallinity, morphology, swelling and model drug release behavior of the Ch/Alg membrane was analyzed. The dynamic swelling behavior of the Ch/Alg and Ch/Alg/TPP membranes were studied in solutions of different pH (1.0–9.0). At pH 7.4 or higher Ch/Alg and Ch/Alg/TPP hydrogels showed an untypical swelling behavior, i.e. “overshooting effect”. The results showed, that addition of TPP reinforced chitosan/alginate network. The swelling/deswelling behavior of the membranes was investigated at pH = 1.5 (or 3.5) and 9 to confirm the response rate and reversibility of the swelling process. Ch/Alg/TPP membranes exhibited sharp swelling/deswelling behavior and high stability in acidic and basic solutions what makes them suitable candidate for drug delivery systems. Drug release of ascorbic acid from Ch/Alg/TPP membrane was measured in buffer solutions of pH = 3.5 and 7.4.

中文翻译：

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三聚磷酸盐增强的pH响应壳聚糖/藻酸盐聚电解质复合膜

摘要 合成了基于壳聚糖/海藻酸盐(Ch/Alg)聚电解质复合物和交联剂三聚磷酸盐(TPP)的pH敏感性壳聚糖/海藻酸盐/三聚磷酸盐(Ch/Alg/TPP)水凝胶膜。分析了 TPP 交联对 Ch/Alg 膜的分子结构、结晶度、形态、溶胀和模型药物释放行为的影响。Ch/Alg 和 Ch/Alg/TPP 膜在不同 pH 值 (1.0-9.0) 的溶液中的动态溶胀行为进行了研究。在 pH 7.4 或更高时，Ch/Alg 和 Ch/Alg/TPP 水凝胶表现出不典型的溶胀行为，即“过冲效应”。结果表明，TPP的添加增强了壳聚糖/藻酸盐网络。在 pH = 1.5（或 3. 5) 和 9 来确认溶胀过程的响应率和可逆性。Ch/Alg/TPP 膜在酸性和碱性溶液中表现出急剧的溶胀/消溶胀行为和高稳定性，这使其成为药物递送系统的合适候选者。在 pH = 3.5 和 7.4 的缓冲溶液中测量抗坏血酸从 Ch/Alg/TPP 膜中的药物释放。