Biocompatible Microporous Organically Modified Silicate Material with Rapid Internal Diffusion of Protons,ACS Sensors

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Biocompatible Microporous Organically Modified Silicate Material with Rapid Internal Diffusion of Protons
ACS Sensors ( IF 8.2 ) Pub Date : 2018-02-23 00:00:00 , DOI: 10.1021/acssensors.8b00024
Christian Grundahl Frankær _{1,

2} , Kishwar J. Hussain ₂ , Martin Rosenberg ₁ , Anders Jensen ₁ , Bo W. Laursen ₁ , Thomas Just Sørensen _{1,

2}

Affiliation

A new four-component organically modified silicate (ORMOSIL) material was developed with optical pH sensors in mind. Through a sol–gel process, the porosity of an ORMOSIL framework was optimized to allow rapid diffusion of protons, ideal for fast response to pH in an optical sensor. The optically transparent material was produced by catalyzing the dual polymerization of 3-(glycidoxy)propyltrimethoxysilane (GPTMS) and propyltriethoxysilane (PrTES) with boron trifluoride diethyl etherate. The performance of the resulting material in fluorescence based optical pH sensors was evaluated by incorporation of active dye components in the inorganic polymer framework. It is demonstrated that the material has a short response time (t₉₀ < 30 s) and high stability in medium and during storage, and resulting sensor spots are biocompatible. It is concluded that this ORMOSIL material has excellent properties for optical pH sensors.

中文翻译：

质子内部快速扩散的生物相容性微孔有机改性硅酸盐材料

考虑到光学pH传感器，开发了一种新的四组分有机改性硅酸盐（ORMOSIL）材料。通过溶胶-凝胶工艺，优化了ORMOSIL框架的孔隙率，以允许质子快速扩散，是光学传感器对pH值快速响应的理想选择。通过催化3-（环氧丙氧基）丙基三甲氧基硅烷（GPTMS）和丙基三乙氧基硅烷（PrTES）与三氟化硼二乙醚的双重聚合反应来生产光学透明材料。通过将活性染料组分掺入无机聚合物骨架中，评估了所得材料在基于荧光的光学pH传感器中的性能。结果表明，该材料的响应时间短（t ₉₀<30 s）且在培养基和储存过程中具有很高的稳定性，因此产生的传感器斑点具有生物相容性。可以得出结论，这种ORMOSIL材料对于光学pH传感器具有优异的性能。

更新日期：2018-02-23

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