A clinical trial showed that efavirenz 400 mg once daily (EFV400) is as effective as the standard adult dose. World Health Organization recommends EFV400 as an alternative first-line agent, but data are lacking in the third trimester of pregnancy (TT). We investigated the pharmacokinetics, efficacy, and CYP2B6 pharmacogenetics in HIV-infected women (WLWH) on EFV400 during TT and post-partum (PP).

中文翻译：

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依法韦仑400 mg的药代动力学，药效动力学和药代动力学在妊娠和产后每天一次

一项临床试验表明，依非韦伦400毫克每天一次（EFV400）与成人标准剂量一样有效。世界卫生组织建议使用EFV400作为替代一线药物，但妊娠中期（TT）缺乏数据。我们在TT和产后（PP）期间，对EFV400上被HIV感染的妇女（WLWH）进行了药代动力学，药效学和CYP2B6药物遗传学研究。