Strain energy-based constitutive laws with damage effect were proposed by using existing both uniaxial tensile test and tubular biaxial inflation test data on the human great saphenous vein (GSV) segments. These laws were applied into GSV coronary artery bypass grafts (CABG) by employing a thin-walled vessel model to evaluate their passive biomechanical performance under coronary artery physiological conditions at a fixed axial pre-stretch. At a peak systolic pressure in 100–150 mmHg, a 20–33% GSV diameter dilation was predicted with the law based on tubular biaxial inflation test data and agreed well with 25% dilation in clinical observation in comparison with as small as 2–4% dilation estimated with the law based on uniaxial tensile test data. The constitutive law generated by tubular biaxial inflation test data was mostly suitable for GSV CABG under coronary artery physiological conditions than that based on uniaxial tensile test results. With these laws, the fibre ultimate stretch was extracted from uniaxial tensile test data and the structural sub-failure/damage threshold of 1.0731 was decided for the human GSV. GSV fibres could exhibit damage effect but unlikely undergo a structure failure/break, suggesting a damage factor might exist during CABG arterialization. The damage in GSV tissue might initiate or contribute to early remodelling of CABG after implantation.

通过使用现有的人类大隐静脉（GSV）段上的单轴拉伸试验和管状双轴膨胀试验数据，提出了具有损伤效应的基于应变能的本构定律。通过采用薄壁血管模型评估固定冠状动脉生理条件下固定轴向预拉伸下的被动生物力学性能，将这些定律应用于GSV冠状动脉搭桥术（CABG）。在收缩压峰值为100-150 mmHg的情况下，根据管状双轴膨胀试验数据，依法可预测GSV直径扩张为20-33％，与临床观察中的小至2-4相比，在临床观察中与25％的扩张非常吻合根据单轴拉伸试验数据，用定律估算％膨胀率。与基于单轴拉伸试验的结果相比，管状双轴充气试验数据产生的本构律最适合冠状动脉生理条件下的GSV CABG。利用这些定律，从单轴拉伸试验数据中提取出纤维的最终拉伸，并确定了人GSV的亚结构破坏/破坏阈值为1.0731。GSV纤维可能具有损伤作用，但不太可能发生结构破坏/断裂，这表明在CABG动脉化过程中可能存在损伤因素。GSV组织中的损伤可能在植入后开始或促进CABG的早期重塑。从单轴拉伸试验数据中提取纤维的极限拉伸强度，并确定人GSV的亚结构破坏/破坏阈值为1.0731。GSV纤维可能具有损伤作用，但不太可能发生结构破坏/断裂，这表明在CABG动脉化过程中可能存在损伤因素。GSV组织中的损伤可能在植入后开始或促进CABG的早期重塑。从单轴拉伸试验数据中提取出纤维的极限拉伸力，并确定了人GSV的亚结构破坏/破坏阈值为1.0731。GSV纤维可能具有损伤作用，但不太可能发生结构破坏/断裂，这表明在CABG动脉化过程中可能存在损伤因素。GSV组织中的损伤可能在植入后开始或促进CABG的早期重塑。