Polyphenolic Compounds Alter Stress‐Induced Patterns of Global DNA Methylation in Brain and Blood,Molecular Nutrition & Food Research

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Polyphenolic Compounds Alter Stress‐Induced Patterns of Global DNA Methylation in Brain and Blood
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2018-03-22 , DOI: 10.1002/mnfr.201700722
Jennifer Blaze ₁ , Jun Wang _{2,

3} , Lap Ho ₂ , Natalia Mendelev ₁ , Fatemeh Haghighi _{1,

3} , Giulio Maria Pasinetti _{2,

3,

4}

Affiliation

Stress is a known contributor to various forms of disease in humans and animals, although mechanisms are still unknown. In animals, psychosocial stress‐induced depression/anxiety phenotypes are coincidental with increased inflammation in both brain and blood. The authors recently showed that a novel treatment with a select bioactive polyphenol preparation promotes resilience to stress‐mediated depression/anxiety phenotypes mice. Moreover, selective bioactive phenolic compounds within the polyphenol preparation are identified that are effective in mitigating the behavioral effects of bone marrow transplantation from stressed mice.

中文翻译：

多酚化合物改变大脑和血液中应激诱导的整体 DNA 甲基化模式

压力是人类和动物各种疾病的已知诱因，但其机制仍不清楚。在动物中，社会心理压力引起的抑郁/焦虑表型与大脑和血液中炎症的增加同时发生。作者最近表明，采用精选生物活性多酚制剂进行的新型治疗可提高小鼠对压力介导的抑郁/焦虑表型的恢复能力。此外，多酚制剂中的选择性生物活性酚类化合物经鉴定可有效减轻应激小鼠骨髓移植的行为影响。

更新日期：2018-03-22

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