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Assessing the phenolic profile, antioxidant, antidiabetic and protective effects against oxidative damage in human erythrocytes of peaches from Fundão
Journal of Functional Foods ( IF 3.8 ) Pub Date : 2018-02-22 , DOI: 10.1016/j.jff.2018.02.018
Catarina Bento , Ana C. Gonçalves , Branca Silva , Luís R. Silva

In this work, the phenolic profile and biological potential of six peach cultivars from Fundão region (Portugal) were evaluated. The LC-DAD analysis revealed a total of 3 anthocyanins, and 14 non-colored phenolics. The antioxidant potential was evaluated against DPPH and NO radicals. Royal Lu proved to be the most active against DPPH (IC50 = 62.1 ± 1.5 μg/mL), and Sweet Dreams was the most active against NO radical (IC50 = 256.7 ± 60.4 μg/mL). Regarding the α-glucosidase inhibitory activity, Royal Magister and Royal Glory present the highest activity (IC50 = 11.7 ± 1.4 and 17.1 ± 1.7 μg/mL, respectively). Finally, the protective effect of Royal Lu to prevent oxidative damage in human erythrocytes induced by ROO was performed. Royal Lu proved to be quite efficient with promising results for hemolysis (IC50 = 110.0 ± 4.5 μg/mL) and hemoglobin oxidation inhibition (IC50 = 83.8 ± 6.5 μg/mL).



中文翻译:

评估Fundão桃对人红细胞的酚性,抗氧化剂,抗糖尿病和抗氧化损伤的保护作用

在这项工作中,评估了来自Fundão地区(葡萄牙)的六个桃品种的酚类特征和生物潜力。LC-DAD分析显示总共3种花色苷和14种无色酚类。评估了抗DPPH和NO自由基的抗氧化剂潜力。事实证明,Royal Lu对DPPH的活性最高(IC 50  = 62.1±1.5μg/ mL),Sweet Dreams对NO自由基的活性最高(IC 50  = 256.7±60.4μg/ mL)。关于α-葡萄糖苷酶的抑制活性,Royal MagisterRoyal Glory表现出最高的活性(IC 50 分别为11.7±1.4和17.1±1.7μg/ mL)。最后,进行了Royal Lu防止由ROO引起的人红细胞氧化损伤的保护作用。事实证明,Royal Lu的溶血作用(IC 50  = 110.0±4.5μg/ mL)和抑制血红蛋白氧化作用(IC 50  = 83.8±6.5μg/ mL)效果非常好。

更新日期:2018-02-22
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