Dysbiosis of the gut flora accompanies Parkinson disease (PD), yet no specific cause-effect link has been identified so far. The gut microbiota produce molecular hydrogen (H2), a ubiquitous molecule recently recognized as a biologically active gas with antioxidant, antiapoptotic, anti-inflammatory, cytoprotective, and signaling properties. Here, we discuss an idea that an impaired production of endogenous H2 by intestinal microbiota might play a role in PD pathogenesis, with supplemental H2 debated as a possible therapy for this progressive neurodegenerative disease.

中文翻译：

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肠道微生物群产生的 H 2 不足和帕金森病

肠道菌群失调伴随帕金森病 (PD)，但迄今为止尚未确定具体的因果关系。肠道微生物群产生分子氢 (H2)，这是一种普遍存在的分子，最近被认为是具有抗氧化、抗凋亡、抗炎、细胞保护和信号传导特性的生物活性气体。在这里，我们讨论了一种观点，即肠道微生物群对内源性 H2 的产生受损可能在 PD 发病机制中发挥作用，补充 H2 被认为是这种进行性神经退行性疾病的可能疗法。