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Optofluidic Immunosensor Based on Resonant Wavelength Shift of a Hollow Core Fiber for Ultratrace Detection of Carcinogenic Benzo[a]pyrene
ACS Photonics ( IF 6.5 ) Pub Date : 2018-02-22 00:00:00 , DOI: 10.1021/acsphotonics.7b01009 Ran Gao 1 , Dan-Feng Lu 1 , Meng-Ying Zhang 1 , Zhi-Mei Qi 1
ACS Photonics ( IF 6.5 ) Pub Date : 2018-02-22 00:00:00 , DOI: 10.1021/acsphotonics.7b01009 Ran Gao 1 , Dan-Feng Lu 1 , Meng-Ying Zhang 1 , Zhi-Mei Qi 1
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Polycyclic aromatic hydrocarbons (PAHs) are always regarded as contaminants originating from the incomplete combustion of organic compounds. Benzo[a]pyrene (B[a]P) can be adopted as a marker for the overall PAH mixture due to its ultratoxic property, which can cause cancer of the lungs, skin, and prostate. It is necessary to monitor the B[a]P contamination levels in a water environment. In this article, an in-line fiber optofluidic sensor for the detection of B[a]P in water by using an antiresonant reflecting optical waveguide is proposed and experimentally demonstrated. One air hole in the cladding of the hollow-core fiber was fabricated as an in-line fiber optofluidic combined with two inlet and outlet microchannels fabricated by using femtosecond laser micromachining. The B[a]P molecule can be detected through the antiresonant reflecting optical waveguide due to the immunoreaction between the antibody and the target B[a]P. The experimental results show that a sensitivity of up to 23 pm/pM is achieved. The proposed fiber sensor appears to have potential applications in research on environmental contamination, food safety, human health, etc.
中文翻译：
基于中空芯纤维共振波长位移的光流免疫传感器用于痕量致癌苯并[a] re的超痕量检测
多环芳烃（PAH）始终被视为源自有机化合物不完全燃烧的污染物。苯并[a] py（B [a] P）可以用作整个PAH混合物的标志物，因为它具有超强的毒性，可引起肺部，皮肤和前列腺癌。有必要监测水环境中的B [a] P污染水平。在本文中，提出了一种在线光纤光电传感器，该传感器通过使用反共振反射光波导来检测水中的B [a] P。中空纤维包层中的一个气孔被制成在线光纤光缆，并结合了两个通过使用飞秒激光微加工制造的入口和出口微通道。由于抗体与靶标B [a] P之间的免疫反应，可以通过反共振反射光波导检测B [a] P分子。实验结果表明，可获得高达23 pm / pM的灵敏度。拟议中的光纤传感器在环境污染，食品安全，人类健康等方面的研究中似乎具有潜在的应用。
更新日期：2018-02-22
中文翻译：
基于中空芯纤维共振波长位移的光流免疫传感器用于痕量致癌苯并[a] re的超痕量检测
多环芳烃（PAH）始终被视为源自有机化合物不完全燃烧的污染物。苯并[a] py（B [a] P）可以用作整个PAH混合物的标志物，因为它具有超强的毒性，可引起肺部，皮肤和前列腺癌。有必要监测水环境中的B [a] P污染水平。在本文中，提出了一种在线光纤光电传感器，该传感器通过使用反共振反射光波导来检测水中的B [a] P。中空纤维包层中的一个气孔被制成在线光纤光缆，并结合了两个通过使用飞秒激光微加工制造的入口和出口微通道。由于抗体与靶标B [a] P之间的免疫反应，可以通过反共振反射光波导检测B [a] P分子。实验结果表明，可获得高达23 pm / pM的灵敏度。拟议中的光纤传感器在环境污染，食品安全，人类健康等方面的研究中似乎具有潜在的应用。
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