Resveratrol has anti-cancer effects in vitro, and hypothetical chemopreventive effects in vivo. Effects are pleiotropic, mediated by changes in expression of many genes and epigenetic reprogramming. Thus, they are well suited for functional genomic studies. We carried out systematic review of such studies (reflecting also on technological progress). Differentially expressed genes commonly linked to resveratrol treatment were linked to cell cycle, proliferation, and apoptosis. However, it is unclear if these are primary and specific targets of resveratrol. We conclude by discussing areas where additional functional genomic studies are desirable, including experiments that better model in vivo effects of dietary intake.

白藜芦醇在体外具有抗癌作用，在体内具有假设的化学预防作用。效果是多效的，由许多基因表达的变化和表观遗传重编程介导。因此，它们非常适合功能基因组研究。我们对此类研究进行了系统评价（也反映了技术进步）。通常与白藜芦醇治疗相关的差异表达基因与细胞周期，增殖和凋亡相关。但是，尚不清楚这些是否是白藜芦醇的主要和特定目标。最后，我们讨论了需要进行其他功能基因组研究的领域，其中包括可以更好地模拟饮食摄入的体内效应的实验。