Molecularly Selective Regulation of Delivery Fluxes by Employing Supramolecular Interactions in Layer‐by‐Layer Films,Chemistry - An Asian Journal

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Molecularly Selective Regulation of Delivery Fluxes by Employing Supramolecular Interactions in Layer‐by‐Layer Films
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2018-03-25 , DOI: 10.1002/asia.201800276
Tao Huang ₁ , Xinglong Luan _{1,

2} , Qi Xia ₁ , Shaofeng Pan ₁ , Qi An ₁ , Yaling Wu ₃ , Yihe Zhang ₁

Affiliation

The molecularly selective regulation of molecular fluxes in a biomaterial that delivers multiple chemical species simultaneously is still beyond the reach of materials scientists. A delivery material was developed by means of the layer‐by‐layer (LbL) technique. This material discriminatively regulates the delivery flux of bioactive small molecules, as represented by a peptide containing the RGD fragment and the chemotherapy drug doxorubicin (DOX). Molecularly selective flux regulations in LbL films are realized through fast, reversible supramolecular interactions between cyclodextrin and its guests. The mechanism underlining the delivery strategy is that supramolecular interactions promote molecular loading and slow down diffusion‐dependent release. In a preliminary survey of materials parameters, a maximum difference in cell viability between healthy human bronchial epithelial cells and cancer cells (A549) was realized.

中文翻译：

利用层状薄膜中的超分子相互作用分子对通量的分子选择性调控

同时传递多种化学物质的生物材料中分子通量的分子选择性调控仍然超出材料科学家的能力范围。交付材料是通过逐层（LbL）技术开发的。这种材料可区别地调节生物活性小分子的输送通量，如含有RGD片段和化疗药物阿霉素（DOX）的肽所代表。LbL膜中的分子选择性通量调节是通过环糊精与其来宾之间的快速，可逆的超分子相互作用实现的。强调递送策略的机制是超分子相互作用促进分子负载并减慢扩散依赖性释放。在材料参数的初步调查中，

更新日期：2018-03-25

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