The medicinal compositions or active components in medicinal plants are the major sources to find new drugs or lead compounds. Exploring novel sorbents with good selectivity for extraction and separation of medicinal compositions or active components from complex medicinal plants are interesting and challenging. Metal-organic frameworks (MOFs) show great potential in adsorption and extraction recently. Herein, we report our primary attempt of zeolitic imidazolate framework-8 (ZIF-8) as a model MOF for selective extraction of a flavonoid named 3,4-dihydroxy-8,9-methylenedioxypterocarpan (compound 1) from a traditional medicinal plant Caragana Jubata. The enrichment factor of ZIF-8 for compound 1 is 57.7. The recoveries of compound 1 at three spiked levels (50, 100, 150 mg L⁻¹) in Caragana Jubata dichloromethane extract are 62.1%, 66.4%, and 75.4%, respectively, with the relative standard deviations of less than 2.9%. The compound 1 also gave good linearity (R² of 0.999) in the concentration range of 5–1000 mg L⁻¹. The obtained compound 1 gave highly antioxidant activity (DPPH radical scavenging rate of 79.03%, inhibitory rate on lipid peroxidation of 75.30%, which were higher than the positive controls Vitamin C and BHT) and low IC₅₀ values (5.438 ± 0.068, 20.970 ± 0.083 μg mL⁻¹ for DPPH radical scavenging activities and inhibitory effects on lipid peroxidation, respectively). These results demonstrated the feasibility of MOFs in selective extraction of medicinal compositions or active components from complex medicinal plants. The current work may open a new way of MOFs in selective extraction of pharmacological active components from medicinal plants.

药用植物中的药用组合物或活性成分是寻找新药或先导化合物的主要来源。探索具有良好选择性的新型吸附剂，用于从复杂药用植物中提取和分离药用组合物或活性成分，是一项有趣且具有挑战性的工作。金属有机骨架（MOF）最近在吸附和提取方面显示出巨大潜力。在这里，我们报告我们的沸石咪唑盐骨架8（ZIF-8）作为模型MOF的主要尝试，该模型用于从传统药用植物柠条植物中选择性提取名为3,4-二羟基-8,9-亚甲基二氧基翼果聚糖（化合物1）的类黄酮。朱巴塔。ZIF-8对化合物1的富集系数为57.7。化合物3在3种加标水平（50,100,150 mg L ^-1）的回收率。Caragana Jubata二氯甲烷萃取物分别为62.1％，66.4％和75.4％，相对标准偏差小于2.9％。化合物1在5–1000 mg L ^-1的浓度范围内也具有良好的线性（R ²为0.999）。所得化合物1具有较高的抗氧化活性（DPPH自由基清除率为79.03％，脂质过氧化抑制率为75.30％，高于阳性对照维生素C和BHT），IC ₅₀值较低（5.438±0.068，20.970± 0.083μg毫升^-1（分别用于DPPH自由基清除活性和对脂质过氧化的抑制作用）。这些结果证明了MOF在从复杂药用植物中选择性提取药用组合物或活性成分的可行性。当前的工作可能为从药用植物中选择性提取药理活性成分开辟MOF的新途径。