Conjugate Additions of Amines to Maleimides via Cooperative Catalysis,Advanced Synthesis & Catalysis

当前位置： X-MOL 学术 › Adv. Synth. Catal. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Conjugate Additions of Amines to Maleimides via Cooperative Catalysis
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2018-03-07 , DOI: 10.1002/adsc.201800160
Brice E. Uno ₁ , Kristine K. Deibler ₁ , Carlos Villa ₂ , Arjun Raghuraman ₂ , Karl A. Scheidt ₁

Affiliation

A cooperative system comprising of a lithium Lewis acid and amine base significantly enhances the rate of the conjugate addition of a wide array of amines to maleimides. This operationally simple, scalable method provides mono‐addition products in high yields and purity. This conjugation was successfully applied to the kinase inhibitor crizotinib in a chemoselective ligation to create novel fluorescent probe.

中文翻译：