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Method for the Fabrication of Elastomeric Polyester Scaffolds for Tissue Engineering and Minimally Invasive Delivery
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2018-02-21 00:00:00 , DOI: 10.1021/acsbiomaterials.7b01017 Miles Montgomery , Locke Davenport Huyer , Dawn Bannerman , Mohammad Hossein Mohammadi , Genevieve Conant , Milica Radisic 1
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2018-02-21 00:00:00 , DOI: 10.1021/acsbiomaterials.7b01017 Miles Montgomery , Locke Davenport Huyer , Dawn Bannerman , Mohammad Hossein Mohammadi , Genevieve Conant , Milica Radisic 1
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Using the methods described herein, we have demonstrated how scaffolds can be designed for a number of applications including tissue engineering, biomedical devices and injectable tissues. Details on the methods of polymerization and physical and chemical characterization of poly(octamethylene maleate (anhydride) citrate (POMaC) are described. Two POMaC polymer recipes with different monomer ratios of maleic anhydride and citric acid were synthesized and compared. Mechanical testing was performed on scaffolds of two distinct anisotropic designs to show how scaffold design influences the apparent elasticity in the long and short axis. POMaC scaffolds of various patterns and geometries were fabricated to demonstrate: (1) scaffold function can be determined by scaffold design (e.g., inherent shape-memory or self-assembling tubular structures), and (2) the soft lithography approach to fabricating biodegradable elastomers described here can be used to suit a number of different potential applications.
中文翻译：
用于组织工程和微创递送的弹性体聚酯支架的制造方法
使用本文描述的方法，我们已经证明了如何为多种应用设计支架，包括组织工程，生物医学装置和可注射组织。详细介绍了聚辛酸八亚甲基马来酸酯（酸酐）柠檬酸酯（POMaC）的聚合方法和理化性质，合成了两种不同马来酸酐和柠檬酸单体比例的POMaC聚合物配方，并进行了比较，并进行了机械测试。两种不同的各向异性设计的脚手架，展示了脚手架设计如何影响长轴和短轴上的表观弹性，制造了各种样式和几何形状的POMaC脚手架，以证明：（1）脚手架的功能可以通过脚手架设计来确定（例如，固有形状） -内存或自组装管状结构），
更新日期：2018-02-21
中文翻译：
用于组织工程和微创递送的弹性体聚酯支架的制造方法
使用本文描述的方法，我们已经证明了如何为多种应用设计支架，包括组织工程，生物医学装置和可注射组织。详细介绍了聚辛酸八亚甲基马来酸酯（酸酐）柠檬酸酯（POMaC）的聚合方法和理化性质，合成了两种不同马来酸酐和柠檬酸单体比例的POMaC聚合物配方，并进行了比较，并进行了机械测试。两种不同的各向异性设计的脚手架，展示了脚手架设计如何影响长轴和短轴上的表观弹性，制造了各种样式和几何形状的POMaC脚手架，以证明：（1）脚手架的功能可以通过脚手架设计来确定（例如，固有形状） -内存或自组装管状结构），
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