Pulmonary hyperinflation in chronic obstructive pulmonary disease (COPD) is associated with reduced biventricular end-diastolic volumes and increased morbidity and mortality. The combination of a long-acting β agonist (LABA) and a muscarinic antagonist (LAMA) is more effective in reducing hyperinflation than LABA-inhaled corticosteroid combination therapy but whether dual bronchodilation improves cardiac function is unknown.

中文翻译：

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茚达特罗加格隆溴铵对肺通气对过度充气和COPD（CLAIM）患者心室充盈的影响：一项双盲，随机，交叉，安慰剂对照，单中心试验。

慢性阻塞性肺疾病（COPD）中的肺过度充气与双心室舒张末期容积减少以及发病率和死亡率增加有关。长效β激动剂（LABA）和毒蕈碱拮抗剂（LAMA）的组合比吸入LABA的皮质类固醇联合疗法在减少恶性通气方面更有效，但支气管双重扩张是否能改善心脏功能尚不清楚。