Tracking the Oxygen Status in the Cell Nucleus with a Hoechst‐Tagged Phosphorescent Ruthenium Complex,ChemBioChem

当前位置： X-MOL 学术 › ChemBioChem › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Tracking the Oxygen Status in the Cell Nucleus with a Hoechst‐Tagged Phosphorescent Ruthenium Complex
ChemBioChem ( IF 2.6 ) Pub Date : 2018-04-14 , DOI: 10.1002/cbic.201700685
Daiki Hara ₁ , Yui Umehara ₁ , Aoi Son ₁ , Wataru Asahi ₂ , Sotaro Misu ₂ , Ryohsuke Kurihara ₂ , Teruyuki Kondo ₁ , Kazuhito Tanabe ₂

Affiliation

An oxygen‐sensing probe for use in the cell nucleus was designed. We prepared “Ru‐Hoechsts”, each consisting of a phosphorescent ruthenium complex linked to a Hoechst 33258 moiety, and characterized their properties as oxygen sensors. The Ru‐Hoechsts accumulated in the cell nucleus and showed oxygen‐dependent signals allowing visualization of oxygen fluctuations in the nucleus.

中文翻译：

用Hoechst标记的磷光钌配合物跟踪细胞核中的氧状态

设计了用于细胞核的氧气感应探针。我们制备了“ Ru-Hoechsts”，每种由与Hoechst 33258部分相连的磷光钌配合物组成，并表征了其作为氧传感器的特性。Ru-Hoechsts积累在细胞核中，并显示出氧依赖性信号，从而可以观察到氧在核中的波动。

更新日期：2018-04-14

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11