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FISH-ing Novel Dynamic Modes of Glucocorticoid-Induced Chromatin Reorganization
Trends in Endocrinology & Metabolism ( IF 11.4 ) Pub Date : 2018-04-01 , DOI: 10.1016/j.tem.2018.02.003
Felicity E. Stubbs , Benjamin P. Flynn , Becky L. Conway-Campbell

In a recent study, Jubb et al. used 3D DNA FISH to assess glucocorticoid-induced 'chromatin decompaction' at multiple loci. Determinants of the specificity, speed, and duration of this phenomenon further enhance our understanding of how the glucocorticoid receptor (GR) dynamically alters chromatin accessibility during acute-phase transcriptional regulation and beyond.

中文翻译:

FISH-ing 糖皮质激素诱导染色质重组的新动态模式

在最近的一项研究中,Jubb 等人。使用 3D DNA FISH 在多个位点评估糖皮质激素诱导的“染色质分解”。这种现象的特异性、速度和持续时间的决定因素进一步增强了我们对糖皮质激素受体 (GR) 如何在急性期转录调控及以后动态改变染色质可及性的理解。
更新日期:2018-04-01
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