Modeling aspects of the human condition in animals has provided invaluable information on the physiology of all organ systems and has assisted in the development of virtually all new therapeutics. Research in cardiovascular disease, cancer, immunology, and other disciplines has benefited substantially from the availability of animal models that capture aspects of specific human diseases and that have been used effectively to advance new treatments. By comparison, animal models for neurological and psychiatric disorders have faced several unique obstacles. This paper highlights topics covered in a recent Cold Spring Harbor Laboratory meeting charged with examining the status of animal models for mental illness. The consensus of the conference is that despite the difficulties inherent with modeling brain disorders in animals, when used judiciously-fully cognizant that models of specific behavioral or biological aspects cannot completely recapitulate the human disorder-animal research is crucial for advancing our understanding of neuropsychiatric disease.

中文翻译：

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会议报告：我们可以制作人类精神疾病的动物模型吗？

动物人体状况的建模为所有器官系统的生理学提供了宝贵的信息，并有助于开发几乎所有新疗法。心血管疾病、癌症、免疫学和其他学科的研究大大受益于动物模型的可用性，这些模型捕捉特定人类疾病的各个方面，并已被有效地用于推进新的治疗方法。相比之下，神经和精神疾病的动物模型面临着几个独特的障碍。本文重点介绍了最近冷泉港实验室会议中涉及的主题，该会议负责检查精神疾病动物模型的状况。会议的共识是，尽管对动物脑部疾病进行建模存在固有的困难，