Synthesis ( IF 2.2 ) Pub Date : 2018-02-21 , DOI: 10.1055/s-0036-1591769 Srivari Chandrasekhar 1, 2 , Vikram Gaddam 1 , Lavanya Nadella 1, 2 , Genji Sukumar 1 , Prathama Mainkar 2, 3
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Abstract
Stereoselective synthesis of northern fragment of eribulin mesylate is reported by coupling of the C1–C13 fragment with the C28–C35 fragment. The key steps involved in this synthesis are butyllithium-facilitated coupling between sulfone and aldehyde, then Dess–Martin periodinane oxidation followed by samarium(II) iodide mediated desulfonylation.
Stereoselective synthesis of northern fragment of eribulin mesylate is reported by coupling of the C1–C13 fragment with the C28–C35 fragment. The key steps involved in this synthesis are butyllithium-facilitated coupling between sulfone and aldehyde, then Dess–Martin periodinane oxidation followed by samarium(II) iodide mediated desulfonylation.
中文翻译：
从d-甘露糖立体选择性合成甲磺酸依里布林的北部片段。
摘要
据报道，C1–C13片段与C28–C35片段的偶联选择性合成了甲磺酸艾瑞布林北部片段的立体选择性合成。合成过程中的关键步骤是丁基锂促进砜和醛之间的偶联，然后进行Dess-Martin高碘烷氧化，然后由碘化sa（II）介导的脱磺酰作用。
据报道，C1–C13片段与C28–C35片段的偶联选择性合成了甲磺酸艾瑞布林北部片段的立体选择性合成。合成过程中的关键步骤是丁基锂促进砜和醛之间的偶联，然后进行Dess-Martin高碘烷氧化，然后由碘化sa（II）介导的脱磺酰作用。
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