Linear solvation energy relationships (LSERs) were applied to retention on hypercrosslinked polystyrene on silica (HC-Tol) to elucidate the type and relative importance of molecular interactions between model solutes and the HC-Tol stationary phase. Classical amino phase and another hypercrosslinked phase (5-HGN) were used as reference columns. On both the HC-Tol and amino, polar interactions predominate and contribute to retention. Solute volume V has no impact on retention on the amino column, while V has a slightly negative influence on retention for the HC-Tol column. The differences in coefficient v between the amino and the HC-Tol columns might explain why the HC-Tol is capable of group-type separations. 5-HGN phase has smaller a and b values compared to HC-Tol, which means that 5-HGN is not as basic or acidic in terms of hydrogen bonds as is HC-Tol. This suggests that the hydrogen bonding character of the HC-Tol phase arises from its silica substrate.

应用线性溶剂能关系（LSERs）保留在二氧化硅上的超交联聚苯乙烯（HC-Tol）上，以阐明模型溶质与HC-Tol固定相之间分子相互作用的类型和相对重要性。经典的氨基相和另一个超交联相（5-HGN）用作参考柱。在HC-Tol和氨基上，极性相互作用占主导，并有助于保留。溶质体积V对氨基柱的保留没有影响，而V对HC-Tol柱的保留有轻微的负面影响。氨基和HC-Tol色谱柱之间系数v的差异可能解释了为什么HC-Tol能够进行基团类型的分离。5-HGN相具有较小的和b相比HC-托尔，这意味着5-HGN并不如碱性或酸性中的氢键术语是HC-托尔值。这表明HC-Tol相的氢键结合特性是由其二氧化硅底物引起的。