Highlights

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CD40 Ligand deficiency may result in severe B and NK loss over time.

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T cell senescence is a novel finding in adult CD40 Ligand deficiency.

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Long term follow-up of CD40 Ligand deficiency may reveal novel immunological findings.

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CD40 Ligand deficient patients not undergoing HSCT should be closely monitored.

中文翻译：

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成人CD40L缺乏症进展性严重B细胞和NK细胞缺乏症伴T细胞衰老

强调

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随着时间的推移，CD40配体不足可能会导致严重的B和NK丢失。

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T细胞衰老是成人CD40配体缺乏症的新发现。

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CD40配体缺乏症的长期随访可能揭示新的免疫学发现。

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未接受HSCT的CD40配体缺陷患者应严密监测。