On integrating downstream membrane based separation modules with conventional fermentation unit, gluconic acid representing a class of industrially important organic acids could be produced from fermentation of sugar cane juice—a renewable cheap carbon source in an environmentally benign process. Using Gluconobacter oxydans as microbial agents in the bioconversion, the membrane-integrated hybrid fermentation system succeeded in producing 93 g/L gluconic acid of 98% purity with yield of 0.94 g/g and productivity of 6.7 g/L/h. The system performance parameters establish superiority of this novel technology over the existing ones. Against the overwhelmingly practiced batch or semi-batch processes involving multiple energy-intensive unit operations, this continuous production scheme ensures efficient bio-conversion without substrate–product inhibitions in a quite simplified plant characterized by high degree of process intensification.

通过将下游的基于膜的分离模块与常规发酵装置集成在一起，可以从甘蔗汁的发酵中生产出代表一类工业上重要的有机酸的葡萄糖酸，这是一种在环境友好的过程中可再生的廉价碳源。使用氧化葡糖杆菌作为在微生物转化过程中，膜整合杂交发酵系统成功生产了93 g / L纯度为98％的葡萄糖酸，产量为0.94 g / g，生产率为6.7 g / L / h。系统性能参数确立了该新技术相对于现有技术的优越性。相对于涉及多个能源密集型单元操作的压倒性的批量或半批量过程，这种连续生产方案可确保在高度简化的以高度过程强化为特征的工厂中实现有效的生物转化，而不会产生底物-产物的抑制作用。