Abstract A non-skin-penetrating bone-anchored hearing aid (BAHA-attract) with a single-point fixation system was recently developed for single-side deafness or sensorineural hearing loss. Here, we coated hydroxyapatitite (HA)/bone morphogenetic protein-2 (BMP-2)/collagen on the implant screw. To evaluate the osteogenesis induced by the modified titanium implant, we conducted in vitro and in vivo tests. The implant showed increased cell-proliferation of 2.3-fold greater than the control, and ALP activity/calcium mineralization results indicated enhanced osteogenic differentiation. According to oxytetracycline and alizarin expression results, the best enhanced peri-implant bone formation (87 ± 5.2%) was observed in the implant compared to the other groups.

中文翻译：

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用生物成分、胶原蛋白/羟基磷灰石/骨形态发生蛋白-2 涂层的钛植入物加速骨整合，用于骨锚式助听器

摘要 最近开发了一种具有单点固定系统的非皮肤穿透骨锚式助听器（BAHA-attract），用于治疗单侧耳聋或感音神经性听力损失。在这里，我们在种植体螺钉上涂覆了羟基磷灰石 (HA)/骨形态发生蛋白-2 (BMP-2)/胶原蛋白。为了评估改性钛植入物诱导的成骨，我们进行了体外和体内测试。植入物显示出比对照高 2.3 倍的细胞增殖增加，并且 ALP 活性/钙矿化结果表明成骨分化增强。根据土霉素和茜素表达结果，与其他组相比，种植体中种植体周围骨形成的增强效果最好（87±5.2%）。