Abstract The carbonized boronic acid-conjugated fluorescent carbon nanoparticles (FNPs) were crosslinked with carbonized dopamine-conjugated hyaluronic acid (HA) via the diol boronic acid-linked catechol groups [C-FNP] as extracellular targeting ligands and pH responsiveness. Into that C-FNP, the redox-responsive MnO2 nanosheets were loaded to demonstrate quenching effect, which recovered after glutathione (GSH) treatment. The MnO2-loaded C-FNP showed excellent stability and tumor-targeting ability guided to the localized tumor using “on–off” fluorescent switch. Furthermore, paclitaxel (PTX) inside the MnO2-loaded C-FNP performed in vitro and in vivo bioimaging and chemotherapeutic activities analyzed towards cancer and non-cancerous cells.

中文翻译：

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用于体内和体外肿瘤靶向药物递送的氧化还原和 pH 响应荧光碳纳米颗粒-MnO 2 基 FRET 系统

摘要 碳化硼酸偶联荧光碳纳米粒子 (FNPs) 与碳化多巴胺偶联透明质酸 (HA) 通过二醇硼酸连接儿茶酚基团 [C-FNP] 作为细胞外靶向配体和 pH 响应进行交联。将氧化还原响应的 MnO2 纳米片加载到该 C-FNP 中以显示淬火效果，在谷胱甘肽 (GSH) 处理后恢复。负载 MnO2 的 C-FNP 显示出优异的稳定性和肿瘤靶向能力，使用“开-关”荧光开关引导至局部肿瘤。此外，负载 MnO2 的 C-FNP 中的紫杉醇 (PTX) 对癌症和非癌细胞进行了体外和体内生物成像和化疗活性分析。