Abstract In this study, we report Bio-renovation, which is a method to biologically derivatize natural compounds to make drug candidate library. In this method, microorganisms produce various derivatives of natural compounds, thereby converting natural compounds into novel bioactive candidates. Five derivatives of genistein were synthesized by Bio-renovation using Bacillus amyloliquefaciens KCTC 13588. Among the genistein derivatives, 4′-O-isopropyl genistein showed antimicrobial activity against eight strains including methicillin resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA) with MIC and MBC values of 8–128 μg/ml. We could find that 4′-O-isopropyl genistein has higher antimicrobial activity than genistein to gram-positive bacteria.

中文翻译：

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通过微生物系统中的生物转化增强染料木黄酮的抗菌作用

摘要 在这项研究中，我们报告了生物改造，这是一种生物衍生天然化合物以制作候选药物库的方法。在这种方法中，微生物产生天然化合物的各种衍生物，从而将天然化合物转化为新的生物活性候选物。使用解淀粉芽孢杆菌 KCTC 13588 通过 Bio-renovation 合成了五种染料木黄酮衍生物。在染料木黄酮衍生物中，4'-O-异丙基染料木黄酮对八种菌株表现出抗菌活性，包括耐甲氧西林金黄色葡萄球菌 (MRSA) 和甲氧西林敏感金黄色葡萄球菌 (MSSA) ) MIC 和 MBC 值为 8–128 μg/ml。我们可以发现，4'-O-异丙基染料木黄酮对革兰氏阳性菌的抗菌活性高于染料木黄酮。