Background

Lung function is a major predictor of morbidity and mortality. Only a few studies have explored the association between phthalate exposure and lung function.

Objective

To evaluate the association between phthalate exposure and lung function in the elderly.

Methods

A total of 3 repeated-measures surveys were conducted in 559 elderly individuals aged ≥60 years in Seoul, Korea, at 1-year intervals (2012–2015). During each survey, urinary mono-(2-ethyl-5-hydrohexyl) phthalate (MEHHP) (geometric mean, 15.68 μg/L), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) (11.97 μg/L), and mono-n-butyl phthalate (MnBP) (2.09 μg/L) levels were measured; moreover, lung function tests and a structured questionnaire interview were performed. We constructed linear mixed models to assess the association between urinary phthalate metabolite levels and lung function.

Results

A doubling of creatinine-adjusted urinary phthalate metabolite levels was inversely associated with forced expiratory volume in 1 s (L) (β = −0.01, 95% confidence interval [CI]: −0.02, 0.004 for MEHHP; β = −0.02, 95% CI: −0.03, −0.01 for MEOHP; β = −0.01, 95% CI: −0.03, −0.003 for MnBP) and forced vital capacity (L) (β = −0.02, 95% CI: −0.03, −0.001 for MEHHP; β = −0.02, 95% CI: −0.03, −0.004 for MEOHP; β = −0.02, 95% CI: −0.03, −0.001 for MnBP). A doubling of creatinine-adjusted MnBP levels was associated with increased rates of annual decline in forced vital capacity (L/year) (β = −0.01, 95% CI: −0.02, −0.001).

Conclusions

Urinary phthalate metabolite levels were associated with lower lung function and an increased rate of decline in lung function in an elderly population.

中文翻译：

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邻苯二甲酸酯暴露与城市老年人肺功能下降之间的关联：重复测量的纵向研究

背景

肺功能是发病率和死亡率的主要预测指标。只有少数研究探讨了邻苯二甲酸酯暴露与肺功能之间的关系。

客观的

评估邻苯二甲酸盐暴露与老年人肺功能之间的关联。

方法

在韩国首尔，以1年为间隔（2012-2015年），对559名年龄≥60岁的老年人进行了3次重复测量调查。在每次调查中，尿邻苯二甲酸单-（2-乙基-5-氢己基）酯（MEHHP）（几何平均值为15.68μg/ L），邻苯二甲酸单-（2-乙基-5-氧己基）邻苯二甲酸酯（MEOHP）（11.97μg/ L ），并测量邻苯二甲酸单正丁酯（MnBP）（2.09μg/ L）的水平; 此外，还进行了肺功能检查和结构化的问卷调查。我们构建了线性混合模型以评估尿邻苯二甲酸酯代谢物水平与肺功能之间的关联。

结果

肌酐调整后的尿邻苯二甲酸酯代谢物水平加倍与强制呼气量在1 s（L）中呈负相关（β= -0.01，95％置信区间[CI]：-0.02，0.004，对于MEHHP；β= -0.02，95 ％CI：-0.03，-MEOHP为-0.01;β= -0.01，95％CI：-0.03，MnBP为-0.003）和强制肺活量（L）（β= -0.02，95％CI：-0.03，-0.001对于MEHHP;β= -0.02，95％CI：-0.03，-0.004对于MEOHP;β= -0.02，95％CI：-0.03，-0.001对于MnBP）。肌酐调整后的MnBP水平加倍与强迫肺活量（L /年）年下降率增加相关（β= -0.01，95％CI：-0.02，-0.001）。

结论

老年人眼中尿邻苯二甲酸酯代谢物水平与肺功能降低和肺功能下降率增加相关。